About
This SPARQL endpoint contains Rhea reactions data (see statistics), and a snapshot of ChEBI data matching the Rhea release. It is free to access and supports the SPARQL 1.1 Standard.
The query timeout is 20 minutes. All triples are available in the default graph. There are two named graphs: <http://sparql.rhea-db.org/rhea> and <http://sparql.rhea-db.org/chebi>.

Documentation
See Rhea RDF diagrams.

Downloads
See Rhea FTP, containing rhea.rdf and chebi.owl. The chebi.owl file is a snapshot of chebi matching the Rhea (and UniProt) release cycle.

Contact
See feedback form.

How to cite
Thierry Lombardot, Anne Morgat, Kristian B Axelsen, Lucila Aimo, Nevila Hyka-Nouspikel, Anne Niknejad, Alex Ignatchenko, Ioannis Xenarios, Elisabeth Coudert, Nicole Redaschi, Alan Bridge
Updates in Rhea: SPARQLing biochemical reaction data
Nucleic Acids Research, Volume 47, Issue D1, 8 January 2019, Pages D596–D600; doi: 10.1093/nar/gky876
Examples
  1. Select all Rhea reactions (unspecified direction), with "Approved" status
  2. Select the number of approved reactions involving lipids (subclass of CHEBI:18059) based on the ChEBI ontology
  3. Select all approved reactions involving lipids (subclass of CHEBI:18059) based on the ChEBI ontology
  4. Select all approved reactions using CHEBI:29985 (L-glutamate) as small molecule participant
  5. Select all approved reactions using L-glutamate as small molecule participant, by exact InChIKey
  6. Select all approved reactions using L-glutamate as small molecule participant, by partial InChIKey, allowing any charge
  7. Select all approved reactions using L-glutamate (CHEBI:29985) AND L-glutamine (CHEBI:58359) in different reaction sides
  8. Select all approved reactions annotated with a given Pubmed ID (2460092)
  9. Select all approved transport reactions
  10. Select all cross-references (to KEGG, MetaCyc, MACiE, ...) for a given reaction (RHEA:11932)
  11. Select all approved reactions linked to a given EC number (EC 1.1.1.353)
  12. Distribution of reactions according to the first level of enzyme classification (federated query)
  13. Select all compounds and count their occurence in Rhea reactions
  14. Select children of CHEBI:35179 (a 2-oxo carboxylate) in the ChEBI hierarchy (using rdfs:subClassOf), used in Rhea reactions or not
  15. Select all the descendants of CHEBI:35179 (a 2-oxo carboxylate) in the ChEBI hierarchy (using rdfs:subClassOf+), used in Rhea reactions or not
  16. Select children of CHEBI:35179 (a 2-oxo carboxylate) in the ChEBI hierarchy (using rdfs:subClassOf) used in Rhea reaction(s), and show the reaction(s)
  17. Select all the descendants of CHEBI:35179 (a 2-oxo carboxylate) in the ChEBI hierarchy (using rdfs:subClassOf+) used in Rhea reaction(s), and show the reaction(s)
  18. Select the child reaction(s) of a given reaction (RHEA:11628) in the Rhea hierarchy (using rdfs:subClassOf)
  19. Select the descendant reaction(s) of a given reaction (RHEA:11628) in the Rhea hierarchy (using rdfs:subClassOf+)
  20. Select all approved reactions with CHEBI:17815 (a 1,2-diacyl-sn-glycerol) or one of its descendant. Display the EC numbers if the rhea-ec link exists
  21. For a given protein (UniProt entry P15877), show its cofactor and the Rhea reaction(s) that modify the cofactor (federated query)